B2M and inborn error of immunity: A pathway enrichment analysis of the transcriptomics data identified the following pathways: complement and coagulation cascades (C9, SERPING1 and C4BPA), cytokine-cytokine receptor interaction (CX3CR1, IL15, TNFRSF14 and IL1RAP), herpes simplex virus 1 infection (IFIH1, BAX, TNFRSF14 and B2M), B cell receptor signaling pathway (BTK and PTPN6), Toll-like receptor signaling pathway (TLR1 and TOLLIP), JAK–STAT pathway (IL15 and PTPN6) and Human immunodeficiency virus 1 infection and primary immunodeficiency pathways (BAX and B2M) (Figure 5).