The levels of ATG7 were found to be reduced in the cerebral cortex and hippocampus of an AD mouse model, but no changes were detected in temporal cortices on AD patients [124]; ATG7 knockdown mice exhibited a reduction of Aβ secretion accompanied by an increase of intracellular Aβ [125], which further supports a role for ATG7 in the transport of Aβ peptides to multivesicular bodies to be secreted. Here, ATG7 is linked to Alzheimer disease.