NOTCH1 and acute lymphoblastic leukemia: In the UKALL2003 trial, among 162 pediatric T-ALL patients, outcomes correlated with the number of mutations, with five-year OS 82, 88, and 100% for NOTCH1/FBXW7 wildtype, NOTCH1 mutated/FBXW7 wildtype, and NOTCH1/FBXW7 double mutated, respectively [64].