Since it has previously been reported that IL4 treatment inhibits TGFβ-mediated Treg cell differentiation in a STAT6-dependent manner [50], enhanced IL4-producing iNKT cells in α-GalCer-injected Vα14Tg NC mice may account for this decrease of Treg cells, ultimately contributing to AD pathogenesis. The gene discussed is TGFB1; the disease is Alzheimer disease.