FLG and infection: For example, skin barrier weakness that is attributable to a filaggrin deficiency promotes inflammation and T-cell infiltration; colonization or infection with Staphylococcus aureus damages the skin barrier and induces inflammatory responses; local Th2 immune responses further reduce skin barrier function, drive itching, and facilitate dysbiosis in favor of members of the genus Staphylococcus, particularly S aureus [2].