In mouse models of Parkinson’s disease, the downregulation of miR-30e, miR-190, and miR-7 enables NLRP3 and ASC expression, the cleavage of caspase-1, the release of IL-1β and IL-18 cytokines, and the cell death by pyroptosis [91,92,93]. Here, PYCARD is linked to Parkinson disease.