PYCARD and Muckle-Wells syndrome: At the same time, Youm et al. [19] reported that the BHB (β-hydroxybutyrate) ketone metabolite can inhibit the K+ efflux and reduces the degree of oligomerization and ASC speck formation during canonical NLRP3 inflammasome activation in mouse models of familial cold auto-inflammatory syndrome (FCAS) and Muckle-Wells syndrome (MWS).