Renal hypouricemia (RHUC) is a rare heterogeneous inherited disease caused by a dysfunction of the primary renal urate transporters: URAT1 (gene SLC22A12, OMIM #220150) and GLUT9 (gene SLC2A9, OMIM #612076), resulting in impaired tubular transport of UA, insufficient reabsorption, and/or increased secretion by a mechanism of endothelial dysfunction [3,4,5,6,7]. Here, SLC22A12 is linked to endothelial dysfunction.