In order to determine the endostatin levels that discriminate positive predicted outcomes from negative predicted outcomes, the cut-off levels were calculated and estimated to be as follows: the endostatin cut-off levels for AKI were 48 ng × L−1 (85 ng × L−1 for 90% specificity, and 26 ng × L−1 regarding 90% sensitivity), the cut-off level for endostatin to predict 30-day mortality was 47 ng × L−1, and the cut-off level for RRT was 62 ng × L−1 (Figure 2). This evidence concerns the gene COL18A1 and acute kidney injury.