It is also demonstrated that dysregulation of cholesterol efflux signaling in diabetes contribute to the activation of Toll-like receptor-4 (TLR-4), NLR family pyrin domain containing 3 (NLRP3) inflammasome and nuclear transcription factor NF-κB resulting in enhanced inflammation and subsequent development of atherogenesis [17]. This evidence concerns the gene NFKB1 and diabetes mellitus.