In newly diagnosed type 2 diabetic patients, a positive association was observed among PCSK9 serum levels with carotid intima-media thickness brachial-ankle pulse wave velocity , C- reactive protein (CRP), neutrophil, lymphocyte, and white blood cell count , thus serving as an early biomarker arteriosclerosis [31]. The gene discussed is CRP; the disease is type 2 diabetes mellitus.