OSBPL3 and familial pancreatic carcinoma: In addition, the GeneGo MetaCore annotations of each BP suggested that the genes co-expressed with OSBPL3 were involved in cytoskeletal remodeling and ephrin-related pathways and networks such as “Cytoskeleton remodeling_Regulation of actin cytoskeleton organization by the kinase effectors of Rho GTPases”, “Inhibition of ephrin receptors in colorectal cancer”, and “Cell adhesion_Ephrin signaling”; thus, these played essential roles in pancreatic cancer (Figure 9; Supplementary Table S4).