SHMT2 and breast cancer: Chuang et al. found that silencing circ_0072995 decreased the glucose uptake, lactate production, ATP levels, enzymes of hexokinase 2 (HK-2), and lactate dehydrogenase A (LDHA), as well as Glucose transporter 1 (Glut1), leading to the suppression of aerobic glycolysis in BC cells through the miR-149-5p/serine hydroxymethyltransferase 2 (SHMT2) axis, suggesting that circ_0072995 functions as an oncogenic circRNA and promotes BC progression by inducing malignant cell phenotypes and anaerobic glycolysis [65].