SF3B3 and non-small cell lung carcinoma: For instance, circ_100146, which is highly expressed in non-small-cell lung cancer (NSCLC), acts as an miRNA sponge to regulate the expression of multiple downstream mRNAs of splicing factor 3b subunit 3 (SF3B3) by binding miR-361-3p and miR-615-5p, thus inhibiting the proliferation and invasion of NSCLC tumors and promoting cell apoptosis [40].