Circ_0025202 acts as an important regulator of tumor-suppressor and TAM-treatment sensitivity in HR-positive breast cancer cells by sponging miR-182-5p and inhibiting the 3′-untranslated region (UTR) binding of transcription factor forkhead box O3A (FOXO3a), thus inhibiting cell proliferation, colony formation, and migration and increasing cell apoptosis [77]. This evidence concerns the gene FOXO3 and breast carcinoma.