ENO2 and Alzheimer disease: The neuronal marker neuron-specific enolase measured in NDEVs extracts confirmed a high degree of neuronal cargo enrichment, with a mean ± S.E.M. of 5816 ± 142 pg/mL in controls and 6049 ± 153 pg/mL in AD individuals, more than ten-fold higher than levels previously observed in astrocyte-derived exosome extracts [19].