Classical activation of TAMs, as stimulated by LPS, IFN-γ, TNF-α, and HMGB1, generates M1-like phenotypes regarded as antitumor macrophages due to their potential to undermine tumor growth and progression; these macrophages are aggressive in nature and highly phagocytic, and can promote Th1 responses [52,53,54]. Here, HMGB1 is linked to neoplasm.