Other polyadenylation and cleavage factors also promoted the use of proximal PAS, such as Pcf11 or Fip1 in C2C12 cells [130], CPSF6 in human hepatocellular carcinoma cells [131], CSTF2 and CPEB3 in lung adenocarcinoma cells [132], or CSTF2 in bladder carcinoma, through shortening of the RAC1-3′UTR [133], or in TAMR breast cancer cells by shortening and stabilizing the 3′UTR of HuR [134]. Here, CSTF2 is linked to breast cancer.