Furthermore, expression of CPSF5/CFIm25/NUDT21 was reported to be down-regulated in the lungs of patients with idiopathic pulmonary fibrosis (IPF) or mice with pulmonary fibrosis [125], in HEK293 cells [126], and in low/high grade glioma cells [127], causing a global shortening of 3′UTRs. Here, NUDT21 is linked to idiopathic pulmonary fibrosis.