Consistently, ketolytic enzyme expression levels, such as BDH1 and SCOT, are low or undetectable in pancreatic cancer (PANC-1), lung cancer (H1299), and neuroblastoma (SK-N-AS) human cell lines as well as in human glioblastoma in vivo [32,37]. Here, BDH1 is linked to familial pancreatic carcinoma.