Increased levels of leptin produced by the expanded body fat were observed in obese humans as well as in studies with an obesogenic diet applied to animals [35,36]; it is supposed that this substance might represent a possible link between high fat accumulation and an increase in sympathoneural activity, leading to an obesity-induced hypertensive state [37,38]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.