Thus, obesity- or HFD-induced hepatic UCP3 expression would be expected, given the increase of FFA fluxed to the liver and hepatic mitochondrial dysfunction associated with NAFLD [41], suggesting that increased UCP3 expression in male mice may occur in an attempt to protect the liver from obesity-associated damage [42]. The gene discussed is UCP3; the disease is obesity due to melanocortin 4 receptor deficiency.