ACE2 and COVID-19: In the context of COVID19 therapy, steroids were among the first drugs to reduce severity, and the cytokine storm by independent mechanisms: (i) The anti-inflammatory effect of steroids prevented the cytokine storm [40,41]; (ii) ACE2 expression was reduced by inhaled steroids, which reduced the chance of SARS-CoV-2 to infect epithelial cells [42]; (iii) dexamethasone directly blocked the interaction of the SARS-CoV-2 spike protein with ACE2 [43]; (iv) steroids increased the activity of ACE2 in patients, which might have contributed to the organ protective effects of ACE2 [44].