Taken together, these results suggest the involvement of methylation in various hearing loss, sporadic MD and SV genes, as is KCNE1 which is differentially expressed genes in the marginal cells of the mouse SV [28], and ADGRV1 and PCDH15 which encode for proteins forming ankle links in the stereocilia bundle [41,42,43]. The gene discussed is ADGRV1; the disease is hearing loss disorder.