Taken together, these results suggest the involvement of methylation in various hearing loss, sporadic MD and SV genes, as is KCNE1 which is differentially expressed genes in the marginal cells of the mouse SV [28], and ADGRV1 and PCDH15 which encode for proteins forming ankle links in the stereocilia bundle [41,42,43]. Here, ADGRV1 is linked to Menkes disease.