LDHA and in situ carcinoma: The CIS-treated group (p ≤ 0.0001) (p ≤ 0.0001) and the EQ + CIS-treated group (p ≤ 0.01) (p ≤ 0.0001) showed a significant increase in LDHA activity in serum and liver tissue, respectively, as compared to the EQ-treated group (Figure 3A,B).