The rs738409 C > G single nucleotide polymorphism (SNP) in the Patatin-like phospholipase domain containing 3 gene (PNPLA3 or adiponutrin) is strongly associated with the entire spectrum of NAFLD, encompassing NASH, severe fibrosis and HCC [9,10]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.