The rs641738 MBOAT7 variation has also been related to progressive NAFLD and a possible mechanism which supports this association was proposed by Tanaka who demonstrated that MBOAT7 depletion in 3D-spheroids composed by hepatocytes and HSCs, stimulated the release of cytokines, fibrogenic markers and collagen deposition due to the accumulation of the MBOAT7 substrate Lyso-PI lipids [44,46,47]. Here, MBOAT7 is linked to metabolic dysfunction-associated steatotic liver disease.