In dietary models of NASH and HCC, the expression of HDAC8 is regulated by Sterol Regulatory Element Binding Transcription Factor 1 (SREBP1) and exerts its function physically interacting with polycomb protein enhancer of zeste homolog 2 (EZH2) to force aberrant cell proliferation. The gene discussed is HDAC8; the disease is metabolic dysfunction-associated steatohepatitis.