Notably, the knock-out (KO) model when combined with membrane bound o-acyltransferase domain-containing 7 (MBOAT7) silencing runs into metabolic reprogramming towards anaerobic glycolysis, suggesting that the co-absence of TM6SF2 and MBOAT7 genes may synergically induce mitochondrial dysfunctions in hepatocytes thus contributing to the switch towards NASH up to HCC [36,37,38]. This evidence concerns the gene MBOAT7 and metabolic dysfunction-associated steatohepatitis.