Indeed, in a Caucasian father-son pair with NAFLD, obesity and low LDL cholesterol, both had a heterozygous mutation in APOB gene (c.1830-1G > A) which is a pathogenic splicing variant which causes truncated ApoB thus resulting in FHBL and they were heterozygous also for the PNPLA3 rs738409 [62]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.