PNPLA3 and Cirrhosis: Liu et al. reported that the rs58542926 was associated with advanced hepatic fibrosis/cirrhosis in two histologically characterized cohorts encompassing steatosis, steatohepatitis, fibrosis and cirrhosis (combined n = 1074) regardless of other confounders as gender, sex, body mass index (BMI), T2D and PNPLA3 rs738409 genotype [32].