TM6SF2 and hepatocellular carcinoma: Finally, Longo et al. have recently demonstrated that TM6SF2 silencing in HepG2 (TM6SF2−/−) hepatoma cells by clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9), resulted in an increased number of mitochondria with small and globular shape, loss of cistern architecture and ultrastructural electron density which may indicate mitochondrial failure and degeneration.