CD40LG and AL amyloidosis: AL amyloidosis is more commonly seen in association with a small-sized, otherwise indolent, bone marrow (BM)-residing plasma cell clone, but it can occasionally accompany a frankly malignant plasma cell clone fulfilling the features of multiple myeloma (MM), or be associated with IgM-producing B cell clones, such as Waldenström macroglobulinemia [9,10,11].