The NF-κB pathway plays a significant role in cancer cell survival by letting tumour cells escape apoptosis as a downstream effect of Protein kinase B (PKB), also known as AKT pathway activation, leading to inflammation and oxidative stress, which causes cancer cell survival and proliferation through increased expression of cell cycle-related VEGF, inflammatory cytokines, and metastatic genes [21]. The gene discussed is NFKB1; the disease is neoplasm.