The aberrant accumulation of SQSTM1 has been found in gastrointestinal cancer [34], prostate cancer [35], hepatocellular carcinoma [36], breast cancer [37] and lung adenocarcinoma [14], suggesting that SQSTM1 accumulation through autophagy inhibition correlates with cancer progression. The gene discussed is SQSTM1; the disease is hepatocellular carcinoma.