After stimulation of PBMCs with erastin or RSL3, pro-IL-1β protein expression levels were significantly higher in AOSD patients (mean of fold change, 1.40 and 1.26, respectively) compared with HC subjects (0.59, p < 0.05, and 0.62, p < 0.01, respectively) (Figure 2C). Here, IL1B is linked to adult-onset Still disease.