Since prostaglandin-endoperoxide synthase 1 (PTGS1; COX1), one of the predicted target genes of miR-15b-5p and miR-92b-3p, has been shown to modulate the nuclear factor kappa B (NF-κB) signaling pathway, which in turn augments MAOA expression via enhanced binding of Sp1 transcription factor (SP1) with GC box of the proximal MAOA gene promoter, we hypothesized that both miRNAs may regulate PTGS1 via NF-κB-SP1 signaling to modify depression caused by chronic IHR in OSA [11,12]. Here, MAOA is linked to obstructive sleep apnea syndrome.