As an example, several histone lysine methylations were described following transient high glucose levels, associated with persistent transcriptional induction of the RELA gene, coding for the p65 subunit of NF-kB, despite subsequent incubation of cells with normal glucose concentrations; this led to transcriptional activation of target genes implicated in inflammation and endothelial dysfunction [31]. Here, RELA is linked to endothelial dysfunction.