In another model of hypertension in vivo, spontaneously hypertensive rats (SHR) exhibited a significantly higher expression of angiotensin 1α receptor (AT1aR), encoded by Atgr1α, compared to Wistar-Kyoto control rats (WKY), which was associated with an hypomethylation of the Atgr1α promoter [79]. The gene discussed is AGTR1; the disease is hypertensive disorder.