Hepatic protein levels of TGF-β1, known for pro-fibrogenic cytokine to promote HSCs activation or proliferation were drastically normalized by GF and other proteins such as TIMP-1, MMP-1, and MMP-13 which are known as ECMs promoters or degradations as responses of liver fibrosis [24,25]. The gene discussed is TIMP1; the disease is Hepatic fibrosis.