TRAP1 and neoplasm: Interestingly, TRAP1 inhibition of mPTP opening was observed not only in tumor cells [6,26] and hypoxic cellular models [4,65] but also in NRK-52E kidney cells under high glucose conditions prompting oxidative stress [66], in H9C2 myocardial cells exposed to extracellular acidification [67] and in C17.2 neural stem cells [5].