These protein kinases are involved in the activation of transcription factors controlling the expression of pro-inflammatory cytokines, and through the activation of various pathways regulate the assembly of NADPH oxidase and the formation of ROS [24,39].Substances that inhibit the activity of these enzymes can have a great therapeutic potential in the treatment of diseases of the central nervous system, including post-stroke states. The gene discussed is WEE1; the disease is Stroke.