Longitudinal studies have suggested that high blood pressure in midlife is the most substantial vascular risk factor for both AD and vascular dementia (VaD) in later life [4], and it constitutes a major cause for the dysregulation of sustained blood flow [2], which increases the expression of hypoxia-inducible factor 1-α leading to upregulation of the beta-secretase (BACE)1 [5,6]. This evidence concerns the gene BACE1 and Alzheimer disease.