The higher levels of ROS found in cancer cells have been linked to the activation of numerous transcription factors, of which nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and hypoxia-inducible factor 1-alpha (HIF-1α) are some of the most important [17,19,20,21,22,23,24,25]. This evidence concerns the gene HIF1A and cancer.