Since IL-6 is able to induce vasopressin secretion by a direct hypothalamic stimulation and by inducing alveolar basement membrane injury and pulmonary hypoxia and vasoconstriction [44,45,46,47], the pro-inflammatory cytokine may represent the common denominator of both acute respiratory insufficiency and syndrome of inappropriate antidiuresis (SIAD)-related hyponatremia. The gene discussed is IL6; the disease is Hyponatremia.