NOS3 and coronary atherosclerosis: Briefly, Company et al. [45] demonstrated that increased EAT volume was correlated with raised heart weight and enhanced messenger ribonucleic acid (mRNA) expression levels of oxidative stress markers, including down-regulation of glutathione peroxidase (GPx), heme oxygenase (HO-1), and superoxide dismutase (SOD) and up-regulation of endothelial nitric oxide synthase (eNOS) in peri-myocardial EAT of pigs with coronary atherosclerosis.