NOX1 and malignant colon neoplasm: We found that not only are these novel compounds highly potent inhibitors of the function of NOX1, but they also inhibit the expression of NOX1 mRNA and protein in human colon cancer cells and block human growth hormone-induced phosphorylation of the c-Met oncoprotein and interleukin-4 mediated upregulation of NOX1 as well as Stat6 signaling.