NOX1 and malignant colon neoplasm: In a previous study, we found that exposure of LS174T human colon cancer cells to DPI (250 nM) or DTI (10 μM) for 24 h produced a significant (>80%) inhibition of NOX1 mRNA expression without altering the expression levels of the antioxidant enzymes catalase or glutathione peroxidase [17].