Using our recently developed specific NOX1 mouse monoclonal antibody that recognizes the C-terminal region of the NOX1 protein, we confirmed that approximately one-third of human colon cancers and one-half of pre-malignant colonic adenomas express NOX1 protein at a high level; in both conditions, NOX1 expression is significantly greater than that observed in the normal colon [11]. The gene discussed is NOX1; the disease is malignant colon neoplasm.