Considering the essential role of autophagy in early placental development and regulation of OS and the importance of cholesterol transporters in maintaining the successful pregnancy, we hypothesized that dysregulated autophagy and oxidative stress leads to abnormal expression of selected placental membrane transporters (ABCA1, ABCG1, and ABCG2) contributing to poor pregnancy survival in EMC. The gene discussed is ABCG2; the disease is extraskeletal myxoid chondrosarcoma.