It has been reported that chemotherapy drugs or natural plant-derived pigments blocked the highly reactive selenocysteine (Sec) residue of TrxR1, thereby triggering the selenium-compromised thioredoxin reductase-derived apoptotic proteins (SecTRAPs) mediated reactive oxygen species (ROS) accumulation and inducing cell death in several cancer cells [9,10]. Here, TXNRD1 is linked to cancer.