NLRP3 and obesity due to melanocortin 4 receptor deficiency: The pentatricopeptide repeat (PRR) proteins, which belong to the family of leucine-rich repeat-containing (NLR) proteins and detect endogenous ligands produced by obesity, stimulate the cryopyrin/NLR pyrin domain-containing 3 (NLRP3) inflammasome, inducing the synthesis of IL-1β and IL-18 through caspase-1 in macrophages [29].