Based on the established roles of the NLRP3 inflammasome and S1P2 demonstrated in independent studies involving several disease types, such as liver fibrosis [37,38], cerebral ischemia [39,40], and psoriasis [41,42], the current findings suggest a possible clue for the pathogenic mechanism underlying the role of the S1P/S1P2 signaling axis in tissue injuries. This evidence concerns the gene NLRP3 and brain ischemia.