We recently demonstrated that activation of Nrf2 through the inhibition of keap1 using cyanoenone triterpenoid, omaveloxolone, can suppress the development of epilepsy in rat temporal lobe epilepsy (TLE) models alone or in combination with NADPH oxidase inhibitor, AEBSF [7,18,19]. Here, NFE2L2 is linked to temporal lobe epilepsy.