NFE2L2 and neurodegenerative disease: Since many of these epilepsies are acquired conditions following an insult to the brain, such as a prolonged seizure and traumatic brain injury, and since oxidative stress has been observed in animal models of these conditions, as well as in epilepsy patients, targeting oxidative stress by Nrf2 activation (either as a monotherapy or as adjuvant therapy) may provide neuroprotective effects and modify the development of epilepsy and associated neurodegenerative diseases.