In other series of experiments, morpholino oligonucleotide (MO) knockdown of Coq6 or Coq8b (=Adck4) in zebrafish caused apoptosis in the Coq6 knockdown zebrafish embryos [57] and nephrosis phenotype of periorbital and total body edema in the Coq8b knockdown zebrafish embryos [63], mimicking the nephrotic syndrome phenotype of the patients. This evidence concerns the gene COQ8B and nephrosis.