PRKN and amyotrophic lateral sclerosis: The mitophagy process is related to the oxidative stress conditions and central neurodegenerative diseases such as AD, PD, and ALS, etc. Especially in Parkinson’s patients, abnormality of PINK1 and parkin proteins leads to the disruption and accumulation of damaged mitochondria, and promotes oxidative stress in the nervous system [45,80].