NPPB and hydrops fetalis: In patients with impaired renal function, the significance of high NT-proBNP concentrations in the diagnosis of acute HF was similar to its significance in the population of patients with eGFRs > 60 mL/min/1.73 m2; however, that finding was based on the adoption of cut-off thresholds that were double the typical NT-proBNP thresholds used for diagnosing HF in different age groups [13].