Based on data from the available literature, as well as our own experience, multimer analysis should be indicated if there is suspicion of a qualitative VWF defect (2A, 2B), as well as a quantitative deficiency (VWD type 3), acquired von Willebrand’s syndrome (AVWs) or thrombotic thrombocytopenic purpura (TTP). Here, VWF is linked to thrombotic thrombocytopenic purpura.