F8 and von Willebrand disease (hereditary or acquired): The analysis of VWF multimers can be performed in patients to determine the type of VWD and the pathomechanism related to changes in any process during VWF metabolism, in order to evaluate the presence of VWF–HMW multimers in VWF coagulation factor VIII concentrates and VWF concentrate, as well as for monitoring the response to treatment.