Furthermore, algal oil, which is rich in omega-3 PUFAs, has been shown to suppress lung metastasis of B16F10 melanoma by an autophagy mechanism mediated by inactivation of the p38 MAPK and mammalian target of rapamycin (mTOR) and activation of c-Jun N-terminal kinases (JNKs), which leads to the suppression of proinflammatory cytokine production [38]. Here, MTOR is linked to melanoma.