Circulating biomarkers which constitute the typical lipid patient profile (LDL-C, TC, triglyceride, Ox-LDL, Lp-PLA2), inflammatory biomarkers such as hs-CRP, TNF-α, IL-6, adipokines (adiponectin, leptin, FABP4) and homocysteine are related to the high risk of future stroke. The gene discussed is TNF; the disease is stroke disorder.