Other genetic polymorphisms that were observed in patients suffering with BPD, but also in other psychiatric disorders, affect genes involved in hypothalamic-pituitary-adrenal (HPA) axis activity, such as FKBP5 and CRHR, which were found to be present, especially in patients exposed to childhood maltreatment [123,128,129]. This evidence concerns the gene CRHR1 and Borderline personality disorder.