Thus, it was unsurprising that a prospective and investigator-blinded side-by-side comparison of CellSearch (pan-CK) and GILUPI CellCollector (EpCAM and pan-CK double staining) did not show significance in either the total number or the frequency of CTCs detected in both metastatic and nonmetastatic CRC patients [96]. The gene discussed is EPCAM; the disease is colorectal carcinoma.