Therefore, to identify the potential biomarkers related to intracellular protein transport in rectal cancer, a public transcriptomic dataset of rectal cancer (GSE35452) from the Gene Expression Omnibus, National Center for Biotechnology Information (GEO, NCBI, Bethesda, MD, USA) was used and melanophilin (MLPH) was recognized as the most significantly up-regulated gene (GO:0006886). Here, MLPH is linked to rectal cancer.