In 2015, the Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) was developed to recapitulate the four TCGA subgroups by using IHC for p53 and mismatch repair (MMR) proteins, along with sequencing for DNA polymerase ε (POLE) exonuclease domain mutation (EDM) [49]. This evidence concerns the gene POLE and endometrial cancer.